Macrophages // Inflammatory Cell Death // Trained Immunity
we are edit labs
We develop novel technology platforms that target and alter macrophage phenotypes.
Macrophages (MФ) are an extremely plastic cell type, adapting their functional phenotype swiftly and sometimes dramatically in response to environmental cues. Not surprisingly, this unique behavior provides a strong predictive model for clinical disease outcomes. For example, disease associated MФs that are functionally responsible for general wound repair (e.g. immune suppressive, angiogenetic, etc) and pathogenic clearance (e.g. immune promoting, phagocytic, etc), are indicative of poor prognosis in cancer and autoimmune disorders, respectively. What remains unclear is how these functional phenotypes arise, and if the function is driving disease progression or is a symptom of environmental cues. Our lab focuses on harnessing existing and developing novel technology platforms that alter MФ function through environmental manipulation.We believe through the development and use of these technologies we can develop an understanding of A. how environmental cues impactMФ function, B. how MФ function drives disease progression and C. how to harness that information toengineernovel technologies to treat disease.
We're the team behind the science. We make things.