we are edit lab
We seek to uncover how dysregulation or incomplete training of a child’s innate immune system contributes to cancer progression, with the ultimate goal of improving therapies and outcomes for pediatric patients.
Macrophages (MΦ) are remarkably plastic cells that can rapidly and dramatically alter their functional phenotype in response to environmental cues. This adaptability makes them a strong predictive model for clinical outcomes in pediatric diseases. For instance, macrophages that adopt wound-repair–associated phenotypes (e.g., immunosuppressive, pro-angiogenic) or pathogen-clearance phenotypes (e.g., immune-stimulatory, phagocytic) are associated with poor prognosis in cancer and autoimmune disorders, respectively.
What remains unclear is how these distinct functional states arise—and whether macrophage function actively drives disease progression or merely reflects environmental influences. Our lab focuses on leveraging existing and developing novel technological platforms to modulate macrophage function through environmental manipulation. Through these approaches, we aim to understand:
A. how environmental cues shape macrophage function,
B. how macrophage activity influences disease progression, and
C. how to translate this knowledge into innovative technologies to treat pediatric diseases.
What remains unclear is how these distinct functional states arise—and whether macrophage function actively drives disease progression or merely reflects environmental influences. Our lab focuses on leveraging existing and developing novel technological platforms to modulate macrophage function through environmental manipulation. Through these approaches, we aim to understand:
A. how environmental cues shape macrophage function,
B. how macrophage activity influences disease progression, and
C. how to translate this knowledge into innovative technologies to treat pediatric diseases.
Meet Us
We're the team
behind the science.
behind the science.
Our team is united by positivity, a genuine love of science, creative thinking, dedication, and a shared hope for a better future.
