We seek to understand how macrophage phenotypes impact and drive pediatric cancer. We use this knowledge to engineer novel technology platforms that target/alter macrophage phenotypes.
1. Initiation and blockage of inflammatory cell death.
Inflammatory cell death is a mechanism through which pathogens are identified and eliminated. Unsurprisingly, the machinery responsible for this form of cell death is upregulated in MФs. These forms of cell death are implicated in cancer (under-active death) and autoimmune disorders (over-active death). We seek to understand how signaling mechanisms from these forms of cell death impact pediatric disease progression.
2. Induce or reverse trained innate immunity
Through a clinical collaboration with The Pinto and Gardner Labs at Seattle Children’s Research Institute, we are exploring how specific epigenetic markers in primary pediatric patient monocytes can predict MФ functional behavior. We believe these epigenetic marks can train MФ functional response and drive disease progression. If true, these epigenetic maps that were are creating can outline and predict both cancer and therapeutic success. We hope to harness this understanding to develop both clinical biomarker assays and novel tools.